XYplorer Beta Club

Is this possible with XYPlorer scripting capabilities? Any help would be greatly appreciated!

In the GUI? You could try sendkeys (before invoking the configuration via command ID) but this would be more or less a hack

Let XY scripting create a .bat file, putt the necessary reg add / delete commands into it and execute it afterwards

You could do this without any scripting if you wanted, just create a couple .reg files you can just dbl click on.